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Viral shedding : ウィキペディア英語版 | Viral shedding
Viral shedding refers to the expulsion and release of virus progeny following successful reproduction during a host-cell infection. Once replication has been completed and the host cell is exhausted of all resources in making viral progeny, the viruses may begin to leave the cell by several methods.〔N.J. Dimmock et al. "Introduction to Modern Virology, 6th edition." Blackwell Publishing, 2007.〕 The term is used to refer to shedding from a single cell, shedding from one part of the body into another part of the body,〔() Massachusetts Department of Public Health - Rabies Control Plan - CHAPTER 1: GENERAL INFORMATION - "Definitions as Used in this Document () Shedding - The release of rabies virus from the salivary glands into the saliva."〕 and shedding from bodies into the environment where the viruses may infect other bodies.〔(J Infect Dis. 1979 Oct;140(4):610-3 ) article ''Viral shedding patterns of children with influenza B infection''〕 ==Via budding ==
"Budding" through the cell envelope—in effect, borrowing from the cell membrane to create the virus's own viral envelope—is most effective for viruses that need an envelope in the first place. These include enveloped viruses such as HIV, HSV, SARS or smallpox. Prior to budding, the virus may put its own receptor onto the surface of the cell in preparation for the virus to bud through, forming an envelope with the viral receptors already on it. Though budding does not immediately destroy the host cell, this process will slowly use up the cell membrane and eventually lead to the cell's demise. This is also how antiviral responses are able to detect virus-infected cells.〔Owen Pornillos, Jennifer E. Garrus and Wesley I. Sundquist. "Mechanisms of enveloped RNA virus budding." Trends in Cell Biology, Volume 12, Issue 12, 1 December 2002, Pages 569-579〕
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